Invasive melanoma: circular RNA explains the spread

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Researchers have enlarged good molecular and epigenetic mechanisms to explain the strong spread of melanoma.

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Scientists examine the epigenetic silence of CircRNA and how this promotes the spread of melanoma.

Along with DNA and protein, RNA is one of the three essential macromolecules essential for all life forms.

The typical process on the basis of all known life forms involves three steps: The genetic information from our DNA – acting as the "blueprint" of the cell – is converted into a "copy". RNA, thereby helping to make proteins required by the cell.

Most RNA is linear. However, some RNA molecules are circular. These are called circular RNA (CircRNA).

Linear RNA encodes proteins, but very few CircRNAs have a clear function. In fact, the medical community is only just beginning to shed light on CircRNA's contribution to physiology and common disease, writing the authors of a new article.

So what is the role of CircRNA in the spread of melanoma? Senior research author Eva Hernando, Ph.D. – a professor at the Department of Pathology at New York University (NYU) Langone Health – and colleagues began investigating.

Very important question, explained to researchers Cancer cell because metastasis is the cause of 90% of all cancer-related deaths. The key time that cancer has spread to the metastases can determine the outcome for a person with cancer.

Melanoma …


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